My experience with the Misos after living (& loving) with them for 4 1/2 years is the total opposite to Ponty's even though I also have the same amplifier combination.
I 'stumbled' across the speakers quite by accident at the Linn dealer in Chester (Adventures in Hi-fi) when I called in there on another matter related to the Keilidhs, which I was still using at the time after 16 years plus. Knowing that I intended to upgrade the rest of the system which included NAC32/HC/2 x NAP140's, I decided to investigate the speaker end first and after comparing the likes of Proac, Kudos, PMC etc., most of which sounded bright, harsh and/or very forward and lacking a natural body to the sound, I got the 'feeling' that the Miso's were the most likely to sound best in my room was convinced that the Miso's were worth a home loan of the dealers demo pair to confirm that 'feeling', I was right. They worked very well with my old Naim amp combination, therefore I ordered a pair and even when the new ones arrived they still impressed straight out of the box but improved further over time (several weeks).
I upgraded the rest of the system over a little more time moving from the NAC32.5/HC/NAP140 setup to NAC282/SC/2 x NAP200's, then replacing the pre-amp section with the NAC252 & Supercap DR and then replacing the two power amps with a single NAP300 and then finally replacing that with the DR version shortly after it's launch. Most of these developments were made when Naim and Acoustica had 'special offers' running, so not too financially painful and during each upgrading stage the Miso's were capable of illustrating the improvements with absolute ease (much more so than the Kudos, Dynaudio and Focal speakers which had been used on the different occasions spent at the dealers premises for the amp upgrade demos).
For the record, the rest of my system consists of Rega RP10 with Apheta 2, Superline powered by Supercap DR, NAT05XS Tuner, CD5XS with nDAC all installed on Quadraspire Q4 EVO racks.
To me (and not only me), my system sounds so 'right' (and it is used for several hours every day) that I would be afraid to change anything at all now in fear of losing what I already have apart from the NACA5 speaker cable to Super Lumina, probably.
I do hope that you make progress with your project Joe and I will follow it with interest.