Lots of info about this on this site, the web, and in the Audivarana user guide/manual.
my set up on the Mac: max RAM (16gb) of which 13gb allocated to Audirvana. Bluetooth off, Infra red off, not running any apps in the background, Finder disabled, wifi disabled (I.e. Connected via Ethernet cable), nothing connected to USB or HDMI port.
'Maximum/ Extreme' setting in Audirvana itself.
Keep the mini away from Naim equipment, TV, cables, etc.
Use a good quality USB cable.
Doing all of this will give some marginal gains.
I see no point USB cleansing devices as V1's USB implementation is pretty much state of the art, but some have done this too.