I am not sure Huge, placing a subwoofer in a corner is often, but not always recommended, and seems to vary on the design of the subwoofer and whether it has a downward facing driver or a lateral driver, as it produces the most dense standing waves and reduces the possibilities of nulls and excites all possible room nodes in a circular pattern out from the speaker. Having two subwoofers in each corner would be even better to get an averaging effect.
Placing a subwoofer near to the speaker plane close to a wall and within the speakers is an alternate..
But the whole sub placement in a typical living space is a compromise where there are usually no bass traps - hence why a DSP can be useful... and I have ordered a miniDSP to play with
With regard to to your central placement scenario- according to my calculations that is equally advantageous and as fraught as a lateral firing subwoofer in a corner - other than it would give a different set of dimensions to play with for a given room - albeit they would be harmonically related